Generation and characterization of monospecific and bispecific hexavalent trimerbodies

Generation and characterization of monospecific and bispecific hexavalent trimerbodies

Here, we describe a new class of multivalent and multispecific antibody-based reagents for therapy. The molecules, termed “trimerbodies,” use a modified version of the N-terminal trimerization region of human collagen XVIII noncollagenous 1 domain flanked by two flexible linkers as trimerizing scaff...

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Bibliographic Details
Main Authors: Blanco-Toribio, Ana, Sainz-Pastor, Noelia, Álvarez-Cienfuegos, Ana, Merino, Nekane, Cuesta, Ángel M., Sánchez-Martín, David, Bonet, Jaume, Santos-Valle, Patricia, Sanz, Laura, Oliva, Baldo, Blanco, Francisco J., Álvarez-Vallina, Luis
Format: Online
Language:English
Published: Landes Bioscience 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564888/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564888/

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