Just One Position-Independent Lysine Residue Can Direct MelanA into Proteasomal Degradation following N-Terminal Fusion of Ubiquitin

Just One Position-Independent Lysine Residue Can Direct MelanA into Proteasomal Degradation following N-Terminal Fusion of Ubiquitin

N-terminal stable in frame fusion of ubiquitin (Ub) has been shown to target the fusion protein for proteasomal degradation. This pathway, called the Ub fusion degradation (UFD), might also elevate MHC class I (MHC-I) antigen presentation of specific antigens. The UFD, mainly studied on cytosolic pr...

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Bibliographic Details
Main Authors: Setz, Christian, Friedrich, Melanie, Hahn, Sabine, Dörrie, Jan, Schaft, Niels, Schuler, Gerold, Schubert, Ulrich
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564756/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564756/

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