Lamin A tail modification by SUMO1 is disrupted by familial partial lipodystrophy–causing mutations
Lamin A tail domains are SUMO1 modified at K420 (nuclear localization signal) and K486 (Ig-fold). K486 modification requires Ig-fold surface residues E460 and D461 and is reduced by familial partial lipodystrophy–causing mutations G465D and K486N. These results suggest novel mechanisms of functional...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564541/ |