A Histone Acetyltransferase p300 Inhibitor C646 Induces Cell Cycle Arrest and Apoptosis Selectively in AML1-ETO-Positive AML Cells

A Histone Acetyltransferase p300 Inhibitor C646 Induces Cell Cycle Arrest and Apoptosis Selectively in AML1-ETO-Positive AML Cells

AML1-ETO fusion protein (AE) is generated by t(8;21)(q22;q22) chromosomal translocation, which is one of the most frequently observed structural abnormalities in acute myeloid leukemia (AML) and displays a pivotal role in leukemogenesis. The histone acetyltransferase p300 promotes self-renewal of le...

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Bibliographic Details
Main Authors: Gao, Xiao-ning, Lin, Ji, Ning, Qiao-yang, Gao, Li, Yao, Yu-shi, Zhou, Ji-hao, Li, Yong-hui, Wang, Li-li, Yu, Li
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563640/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563640/

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