Rad9, Rad17, TopBP1 and Claspin Play Essential Roles in Heat-Induced Activation of ATR Kinase and Heat Tolerance

Rad9, Rad17, TopBP1 and Claspin Play Essential Roles in Heat-Induced Activation of ATR Kinase and Heat Tolerance

Hyperthermia is widely used to treat patients with cancer, especially in combination with other treatments such as radiation therapy. Heat treatment per se activates DNA damage responses mediated by the ATR-Chk1 and ATM-Chk2 pathways but it is not fully understood how these DNA damage responses are...

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Bibliographic Details
Main Authors: Tuul, Munkhbold, Kitao, Hiroyuki, Iimori, Makoto, Matsuoka, Kazuaki, Kiyonari, Shinichi, Saeki, Hiroshi, Oki, Eiji, Morita, Masaru, Maehara, Yoshihiko
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562228/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562228/

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