Pituitary adenylate cyclase-activating peptide induces long-lasting neuroprotection through the induction of activity-dependent signaling via the cyclic AMP response element-binding protein-regulated transcription co-activator 1
Pituitary adenylate cyclase-activating peptide (PACAP) is a neuroprotective peptide which exerts its effects mainly through the cAMP-protein kinase A (PKA) pathway. Here, we show that in cortical neurons, PACAP-induced PKA signaling exerts a major part of its neuroprotective effects indirectly, by t...
Main Authors: | , , , , |
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Format: | Online |
Language: | English |
Published: |
Blackwell Publishing Ltd
2011
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557719/ |