Inhibition of MerTK increases chemosensitivity and decreases oncogenic potential in T-cell acute lymphoblastic leukemia
Pediatric leukemia survival rates have improved dramatically over the past decades. However, current treatment protocols are still largely ineffective in cases of relapsed leukemia and are associated with a significant rate of chronic health conditions. Thus, there is a continued need for new therap...
Main Authors: | Brandao, L N, Winges, A, Christoph, S, Sather, S, Migdall-Wilson, J, Schlegel, J, McGranahan, A, Gao, D, Liang, X, DeRyckere, D, Graham, D K |
---|---|
Format: | Online |
Language: | English |
Published: |
Nature Publishing Group
2013
|
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556576/ |
Similar Items
-
MerTK is required for apoptotic cell–induced T cell tolerance
by: Wallet, Mark A., et al.
Published: (2008) -
MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme
by: Knubel, Kristina H., et al.
Published: (2014) -
Prolonged Exposure to a Mer Ligand in Leukemia: Gas6 Favors Expression of a Partial Mer Glycoform and Reveals a Novel Role for Mer in the Nucleus
by: Migdall-Wilson, Justine, et al.
Published: (2012) -
Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancer
by: Cummings, Christopher T., et al.
Published: (2014) -
Aberrant Mer receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia
by: Lee-Sherick, A B, et al.
Published: (2013)