A Novel Interaction between hScrib and PP1γ Downregulates ERK Signaling and Suppresses Oncogene-Induced Cell Transformation

A Novel Interaction between hScrib and PP1γ Downregulates ERK Signaling and Suppresses Oncogene-Induced Cell Transformation

Previous studies have shown that the cell polarity regulator hScrib interacts with, and consequently controls, the ERK signaling pathway. This interaction occurs through two well-conserved Kinase Interacting Motifs, which allow hScrib to bind ERK1 directly, resulting in a reduction in the levels of...

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Bibliographic Details
Main Authors: Nagasaka, Kazunori, Seiki, Takayuki, Yamashita, Aki, Massimi, Paola, Subbaiah, Vanitha Krishna, Thomas, Miranda, Kranjec, Christian, Kawana, Kei, Nakagawa, Shunsuke, Yano, Tetsu, Taketani, Yuji, Fujii, Tomoyuki, Kozuma, Shiro, Banks, Lawrence
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554735/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554735/

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