Multiple RNA interactions position Mrd1 at the site of the small subunit pseudoknot within the 90S pre-ribosome

Ribosomal subunit biogenesis in eukaryotes is a complex multistep process. Mrd1 is an essential and conserved small (40S) ribosomal subunit synthesis factor that is required for early cleavages in the 35S pre-ribosomal RNA (rRNA). Yeast Mrd1 contains five RNA-binding domains (RBDs), all of which are...

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Bibliographic Details
Main Authors: Segerstolpe, Åsa, Granneman, Sander, Björk, Petra, de Lima Alves, Flavia, Rappsilber, Juri, Andersson, Charlotta, Högbom, Martin, Tollervey, David, Wieslander, Lars
Format: Online
Language:English
Published: Oxford University Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553979/