Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3′-splice site recognition

Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3′-splice site recognition

Recognition of the 3′-splice site is a key step in pre-mRNA splicing and accomplished by a dynamic complex comprising splicing factor 1 (SF1) and the U2 snRNP auxiliary factor 65-kDa subunit (U2AF65). Both proteins mediate protein–protein and protein–RNA interactions for cooperative RNA-binding duri...

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Bibliographic Details
Main Authors: Zhang, Yun, Madl, Tobias, Bagdiul, Ivona, Kern, Thomas, Kang, Hyun-Seo, Zou, Peijian, Mäusbacher, Nina, Sieber, Stephan A., Krämer, Angela, Sattler, Michael
Format: Online
Language:English
Published: Oxford University Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553976/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553976/

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