Allosteric regulation of DegS protease subunits though a shared energy landscape
The PDZ domains of the trimeric DegS protease bind unassembled outer-membrane proteins (OMPs) that accumulate in the E. coli periplasm. This cooperative binding reaction triggers a proteolytic cascade that activates a transcriptional stress response. To dissect the mechanism of allosteric activation...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551985/ |