Structural Basis of the γ-Lactone-Ring Formation in Ascorbic Acid Biosynthesis by the Senescence Marker Protein-30/Gluconolactonase

Structural Basis of the γ-Lactone-Ring Formation in Ascorbic Acid Biosynthesis by the Senescence Marker Protein-30/Gluconolactonase

The senescence marker protein-30 (SMP30), which is also called regucalcin, exhibits gluconolactonase (GNL) activity. Biochemical and biological analyses revealed that SMP30/GNL catalyzes formation of the γ-lactone-ring of l-gulonate in the ascorbic acid biosynthesis pathway. The molecular basis of t...

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Bibliographic Details
Main Authors: Aizawa, Shingo, Senda, Miki, Harada, Ayaka, Maruyama, Naoki, Ishida, Tetsuo, Aigaki, Toshiro, Ishigami, Akihito, Senda, Toshiya
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551927/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551927/

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