An effort to make sense of antisense transcription in bacteria
Analysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some portion of the 5′- and 3′-UTR regions. The biological advantages of such overl...
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| Format: | Online |
| Language: | English |
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Landes Bioscience
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551857/ |
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pubmed-35518572013-01-24 An effort to make sense of antisense transcription in bacteria Lasa, Iñigo Toledo-Arana, Alejandro Gingeras, Thomas R. Point of View Analysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some portion of the 5′- and 3′-UTR regions. The biological advantages of such overlapping transcription are unclear but may play important regulatory roles at the level of transcription, RNA stability and translation. In a recent report, the human pathogen Staphylococcus aureus is observed to generate genome-wide overlapping transcription in the same bacterial cells leading to a collection of short RNA fragments generated by the endoribonuclease III, RNase III. This processing appears most prominently in Gram-positive bacteria. The implications of both the use of pervasive overlapping transcription and the processing of these double stranded templates into short RNAs are explored and the consequences discussed. Landes Bioscience 2012-08-01 /pmc/articles/PMC3551857/ /pubmed/22858676 http://dx.doi.org/10.4161/rna.21167 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Lasa, Iñigo Toledo-Arana, Alejandro Gingeras, Thomas R. |
| spellingShingle |
Lasa, Iñigo Toledo-Arana, Alejandro Gingeras, Thomas R. An effort to make sense of antisense transcription in bacteria |
| author_facet |
Lasa, Iñigo Toledo-Arana, Alejandro Gingeras, Thomas R. |
| author_sort |
Lasa, Iñigo |
| title |
An effort to make sense of antisense transcription in bacteria |
| title_short |
An effort to make sense of antisense transcription in bacteria |
| title_full |
An effort to make sense of antisense transcription in bacteria |
| title_fullStr |
An effort to make sense of antisense transcription in bacteria |
| title_full_unstemmed |
An effort to make sense of antisense transcription in bacteria |
| title_sort |
effort to make sense of antisense transcription in bacteria |
| description |
Analysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some portion of the 5′- and 3′-UTR regions. The biological advantages of such overlapping transcription are unclear but may play important regulatory roles at the level of transcription, RNA stability and translation. In a recent report, the human pathogen Staphylococcus aureus is observed to generate genome-wide overlapping transcription in the same bacterial cells leading to a collection of short RNA fragments generated by the endoribonuclease III, RNase III. This processing appears most prominently in Gram-positive bacteria. The implications of both the use of pervasive overlapping transcription and the processing of these double stranded templates into short RNAs are explored and the consequences discussed. |
| publisher |
Landes Bioscience |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551857/ |
| _version_ |
1611948745655582720 |