BRCA1 loss activates cathepsin L–mediated degradation of 53BP1 in breast cancer cells

BRCA1 loss activates cathepsin L–mediated degradation of 53BP1 in breast cancer cells

Cathepsin L degrades 53BP1 to overcome genomic instability and growth arrest in BRCA1-deficient and triple-negative breast cancers.

Bibliographic Details
Main Authors: Grotsky, David A., Gonzalez-Suarez, Ignacio, Novell, Anna, Neumann, Martin A., Yaddanapudi, Sree C., Croke, Monica, Martinez-Alonso, Montserrat, Redwood, Abena B., Ortega-Martinez, Sylvia, Feng, Zhihui, Lerma, Enrique, Ramon y Cajal, Teresa, Zhang, Junran, Matias-Guiu, Xavier, Dusso, Adriana, Gonzalo, Susana
Format: Online
Language:English
Published: The Rockefeller University Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549967/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549967/

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