Host Factors Dictate Control of Viral Replication in two HIV-1 Controller/Chronic Progressor Transmission Pairs

Viremic controllers (VC) and elite controllers/suppressors (ES) maintain control over HIV-1 replication. Some studies suggested that control is a result of infection with a defective viral strain while others suggested host immune factors play a key role. Here we document two HIV-1 transmission pair...

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Main Authors:	Buckheit, Robert W., Allen, Tracy G., Alme, Angela, Salgado, Maria, O’Connell, Karen A., Huculak, Sarah, Falade-Nwulia, Oluwaseun, Williams, Thomas M., Gallant, Joel E., Siliciano, Robert F., Blankson, Joel N.
Format:	Online
Language:	English
Published:	2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549550/

id	pubmed-3549550
recordtype	oai_dc
spelling	pubmed-35495502013-01-21 Host Factors Dictate Control of Viral Replication in two HIV-1 Controller/Chronic Progressor Transmission Pairs Buckheit, Robert W. Allen, Tracy G. Alme, Angela Salgado, Maria O’Connell, Karen A. Huculak, Sarah Falade-Nwulia, Oluwaseun Williams, Thomas M. Gallant, Joel E. Siliciano, Robert F. Blankson, Joel N. Article Viremic controllers (VC) and elite controllers/suppressors (ES) maintain control over HIV-1 replication. Some studies suggested that control is a result of infection with a defective viral strain while others suggested host immune factors play a key role. Here we document two HIV-1 transmission pairs: one consisting of a patient with progressive disease and an individual who became an ES, and the second consisting of a patient with progressive disease and a VC. In contrast to another ES transmission pair, virus isolated from all patients was fully replication competent. These data suggests that some VC and ES are infected with HIV-1 isolates that replicate vigorously in vitro and are able to cause progressive disease in vivo. These data suggest that host factors play a dominant role in control of HIV-1 infection, thus it may be possible to control fully pathogenic HIV-1 isolates with therapeutic vaccination. 2012-03-06 /pmc/articles/PMC3549550/ /pubmed/22395607 http://dx.doi.org/10.1038/ncomms1697 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Buckheit, Robert W. Allen, Tracy G. Alme, Angela Salgado, Maria O’Connell, Karen A. Huculak, Sarah Falade-Nwulia, Oluwaseun Williams, Thomas M. Gallant, Joel E. Siliciano, Robert F. Blankson, Joel N.
spellingShingle	Buckheit, Robert W. Allen, Tracy G. Alme, Angela Salgado, Maria O’Connell, Karen A. Huculak, Sarah Falade-Nwulia, Oluwaseun Williams, Thomas M. Gallant, Joel E. Siliciano, Robert F. Blankson, Joel N. Host Factors Dictate Control of Viral Replication in two HIV-1 Controller/Chronic Progressor Transmission Pairs
author_facet	Buckheit, Robert W. Allen, Tracy G. Alme, Angela Salgado, Maria O’Connell, Karen A. Huculak, Sarah Falade-Nwulia, Oluwaseun Williams, Thomas M. Gallant, Joel E. Siliciano, Robert F. Blankson, Joel N.
author_sort	Buckheit, Robert W.
title	Host Factors Dictate Control of Viral Replication in two HIV-1 Controller/Chronic Progressor Transmission Pairs
title_short	Host Factors Dictate Control of Viral Replication in two HIV-1 Controller/Chronic Progressor Transmission Pairs
title_full	Host Factors Dictate Control of Viral Replication in two HIV-1 Controller/Chronic Progressor Transmission Pairs
title_fullStr	Host Factors Dictate Control of Viral Replication in two HIV-1 Controller/Chronic Progressor Transmission Pairs
title_full_unstemmed	Host Factors Dictate Control of Viral Replication in two HIV-1 Controller/Chronic Progressor Transmission Pairs
title_sort	host factors dictate control of viral replication in two hiv-1 controller/chronic progressor transmission pairs
description	Viremic controllers (VC) and elite controllers/suppressors (ES) maintain control over HIV-1 replication. Some studies suggested that control is a result of infection with a defective viral strain while others suggested host immune factors play a key role. Here we document two HIV-1 transmission pairs: one consisting of a patient with progressive disease and an individual who became an ES, and the second consisting of a patient with progressive disease and a VC. In contrast to another ES transmission pair, virus isolated from all patients was fully replication competent. These data suggests that some VC and ES are infected with HIV-1 isolates that replicate vigorously in vitro and are able to cause progressive disease in vivo. These data suggest that host factors play a dominant role in control of HIV-1 infection, thus it may be possible to control fully pathogenic HIV-1 isolates with therapeutic vaccination.
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549550/
_version_	1611948301906608128

Host Factors Dictate Control of Viral Replication in two HIV-1 Controller/Chronic Progressor Transmission Pairs

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