Experimental determination of the oral bioavailability and bioaccessibility of lead particles

In vivo estimations of Pb particle bioavailability are costly and variable, because of the nature of animal assays. The most feasible alternative for increasing the number of investigations carried out on Pb particle bioavailability is in vitro testing. This testing method requires calibration using...

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Main Authors:	Deshommes, Elise, Tardif, Robert, Edwards, Marc, Sauvé, Sébastien, Prévost, Michèle
Format:	Online
Language:	English
Published:	BioMed Central 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547711/

id	pubmed-3547711
recordtype	oai_dc
spelling	pubmed-35477112013-01-23 Experimental determination of the oral bioavailability and bioaccessibility of lead particles Deshommes, Elise Tardif, Robert Edwards, Marc Sauvé, Sébastien Prévost, Michèle Review In vivo estimations of Pb particle bioavailability are costly and variable, because of the nature of animal assays. The most feasible alternative for increasing the number of investigations carried out on Pb particle bioavailability is in vitro testing. This testing method requires calibration using in vivo data on an adapted animal model, so that the results will be valid for childhood exposure assessment. Also, the test results must be reproducible within and between laboratories. The Relative Bioaccessibility Leaching Procedure, which is calibrated with in vivo data on soils, presents the highest degree of validation and simplicity. This method could be applied to Pb particles, including those in paint and dust, and those in drinking water systems, which although relevant, have been poorly investigated up to now for childhood exposure assessment. BioMed Central 2012-11-22 /pmc/articles/PMC3547711/ /pubmed/23173867 http://dx.doi.org/10.1186/1752-153X-6-138 Text en Copyright ©2012 Deshommes et al.; licensee Chemistry Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Deshommes, Elise Tardif, Robert Edwards, Marc Sauvé, Sébastien Prévost, Michèle
spellingShingle	Deshommes, Elise Tardif, Robert Edwards, Marc Sauvé, Sébastien Prévost, Michèle Experimental determination of the oral bioavailability and bioaccessibility of lead particles
author_facet	Deshommes, Elise Tardif, Robert Edwards, Marc Sauvé, Sébastien Prévost, Michèle
author_sort	Deshommes, Elise
title	Experimental determination of the oral bioavailability and bioaccessibility of lead particles
title_short	Experimental determination of the oral bioavailability and bioaccessibility of lead particles
title_full	Experimental determination of the oral bioavailability and bioaccessibility of lead particles
title_fullStr	Experimental determination of the oral bioavailability and bioaccessibility of lead particles
title_full_unstemmed	Experimental determination of the oral bioavailability and bioaccessibility of lead particles
title_sort	experimental determination of the oral bioavailability and bioaccessibility of lead particles
description	In vivo estimations of Pb particle bioavailability are costly and variable, because of the nature of animal assays. The most feasible alternative for increasing the number of investigations carried out on Pb particle bioavailability is in vitro testing. This testing method requires calibration using in vivo data on an adapted animal model, so that the results will be valid for childhood exposure assessment. Also, the test results must be reproducible within and between laboratories. The Relative Bioaccessibility Leaching Procedure, which is calibrated with in vivo data on soils, presents the highest degree of validation and simplicity. This method could be applied to Pb particles, including those in paint and dust, and those in drinking water systems, which although relevant, have been poorly investigated up to now for childhood exposure assessment.
publisher	BioMed Central
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547711/
_version_	1611947765087076352

Experimental determination of the oral bioavailability and bioaccessibility of lead particles

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