Identifying combined design and analysis procedures in two-stage trials with a binary end point
Two-stage trial designs provide the flexibility to stop early for efficacy or futility and are popular because they have a smaller sample size on average than a traditional trial has with the same type I and II error rates. This makes them financially attractive but also has the ethical benefit of r...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Blackwell Publishing Ltd
2012
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546375/ |