Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo
Actinomycin D plays a key role in the successful treatment of Wilms tumour. However, associated liver toxicities remain a drawback to potentially curative treatment. We have used MDCKII cells over-expressing ABCB1, ABCC1, ABCC2 and ABCG2, alongside knockout mouse models to characterise actinomycin D...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Elsevier Science
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545186/ |