Systemic Overexpression of TNFα-converting Enzyme Does Not Lead to Enhanced Shedding Activity In Vivo

Systemic Overexpression of TNFα-converting Enzyme Does Not Lead to Enhanced Shedding Activity In Vivo

TNFα-converting enzyme (TACE/ADAM17) is a membrane-bound proteolytic enzyme with a diverse set of target molecules. Most importantly, TACE is indispensable for the release and activation of pro-TNFα and the ligands for epidermal growth factor receptor in vivo. Previous studies suggested that the ove...

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Bibliographic Details
Main Authors: Yoda, Masaki, Kimura, Tokuhiro, Tohmonda, Takahide, Morioka, Hideo, Matsumoto, Morio, Okada, Yasunori, Toyama, Yoshiaki, Horiuchi, Keisuke
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544834/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544834/

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