Aqp5 Is a New Transcriptional Target of Dot1a and a Regulator of Aqp2

Aqp5 Is a New Transcriptional Target of Dot1a and a Regulator of Aqp2

Dot1l encodes histone H3 K79 methyltransferase Dot1a. Mice with Dot1l deficiency in renal Aqp2-expressing cells (Dot1lAC) develop polyuria by unknown mechanisms. Here, we report that Aqp5 links Dot1l deletion to polyuria through Aqp2. cDNA array analysis revealed and real-time RT-qPCR validated Aqp...

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Bibliographic Details
Main Authors: Wu, Hongyu, Chen, Lihe, Zhang, Xi, Zhou, Qiaoling, Li, Ju-Mei, Berger, Stefan, Borok, Zea, Zhou, Beiyun, Xiao, Zhou, Yin, Hongling, Liu, Mingyao, Wang, Ying, Jin, Jianping, Blackburn, Michael R., Xia, Yang, Zhang, Wenzheng
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542343/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542343/

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