A Cluster-Randomized Controlled Trial Evaluating the Effects of Mass Azithromycin Treatment on Growth and Nutrition in Niger

Antimicrobials are used primarily to treat infectious disease, but they have other effects. Here, we assess anthropometry measurements in children 6–60 months in 24 communities randomized to one or two mass azithromycin distributions over a 1-year period in Niger. We compared the prevalence of wasti...

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Main Authors:	Amza, Abdou, Kadri, Boubacar, Nassirou, Baido, Stoller, Nicole E., Yu, Sun N., Zhou, Zhaoxia, West, Sheila K., Mabey, David C. W., Bailey, Robin L., Keenan, Jeremy D., Porco, Travis C., Lietman, Thomas M., Gaynor, Bruce D.
Format:	Online
Language:	English
Published:	The American Society of Tropical Medicine and Hygiene 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541724/

id	pubmed-3541724
recordtype	oai_dc
spelling	pubmed-35417242013-02-27 A Cluster-Randomized Controlled Trial Evaluating the Effects of Mass Azithromycin Treatment on Growth and Nutrition in Niger Amza, Abdou Kadri, Boubacar Nassirou, Baido Stoller, Nicole E. Yu, Sun N. Zhou, Zhaoxia West, Sheila K. Mabey, David C. W. Bailey, Robin L. Keenan, Jeremy D. Porco, Travis C. Lietman, Thomas M. Gaynor, Bruce D. Articles Antimicrobials are used primarily to treat infectious disease, but they have other effects. Here, we assess anthropometry measurements in children 6–60 months in 24 communities randomized to one or two mass azithromycin distributions over a 1-year period in Niger. We compared the prevalence of wasting, low mid-upper arm circumference, stunting, and underweight in communities in the two treatment arms. We were unable to prove that there was a difference in the prevalence of wasting in the 12 communities that received one mass azithromycin distribution versus the 12 communities that received two mass azithromycin distributions (odds ratio = 0.75, 95% confidence interval = 0.46–1.23). Likewise, we were unable to detect a difference in the two treatment arms for low mid-upper arm circumference, stunting, and underweight. There may not be an association between antibiotic use and improved growth in humans, or this trial was not powerful enough to detect an association if it exists. The American Society of Tropical Medicine and Hygiene 2013-01-09 /pmc/articles/PMC3541724/ /pubmed/23208876 http://dx.doi.org/10.4269/ajtmh.2012.12-0284 Text en ©The American Society of Tropical Medicine and Hygiene This is an Open Access article distributed under the terms of the American Society of Tropical Medicine and Hygiene's Re-use License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Amza, Abdou Kadri, Boubacar Nassirou, Baido Stoller, Nicole E. Yu, Sun N. Zhou, Zhaoxia West, Sheila K. Mabey, David C. W. Bailey, Robin L. Keenan, Jeremy D. Porco, Travis C. Lietman, Thomas M. Gaynor, Bruce D.
spellingShingle	Amza, Abdou Kadri, Boubacar Nassirou, Baido Stoller, Nicole E. Yu, Sun N. Zhou, Zhaoxia West, Sheila K. Mabey, David C. W. Bailey, Robin L. Keenan, Jeremy D. Porco, Travis C. Lietman, Thomas M. Gaynor, Bruce D. A Cluster-Randomized Controlled Trial Evaluating the Effects of Mass Azithromycin Treatment on Growth and Nutrition in Niger
author_facet	Amza, Abdou Kadri, Boubacar Nassirou, Baido Stoller, Nicole E. Yu, Sun N. Zhou, Zhaoxia West, Sheila K. Mabey, David C. W. Bailey, Robin L. Keenan, Jeremy D. Porco, Travis C. Lietman, Thomas M. Gaynor, Bruce D.
author_sort	Amza, Abdou
title	A Cluster-Randomized Controlled Trial Evaluating the Effects of Mass Azithromycin Treatment on Growth and Nutrition in Niger
title_short	A Cluster-Randomized Controlled Trial Evaluating the Effects of Mass Azithromycin Treatment on Growth and Nutrition in Niger
title_full	A Cluster-Randomized Controlled Trial Evaluating the Effects of Mass Azithromycin Treatment on Growth and Nutrition in Niger
title_fullStr	A Cluster-Randomized Controlled Trial Evaluating the Effects of Mass Azithromycin Treatment on Growth and Nutrition in Niger
title_full_unstemmed	A Cluster-Randomized Controlled Trial Evaluating the Effects of Mass Azithromycin Treatment on Growth and Nutrition in Niger
title_sort	cluster-randomized controlled trial evaluating the effects of mass azithromycin treatment on growth and nutrition in niger
description	Antimicrobials are used primarily to treat infectious disease, but they have other effects. Here, we assess anthropometry measurements in children 6–60 months in 24 communities randomized to one or two mass azithromycin distributions over a 1-year period in Niger. We compared the prevalence of wasting, low mid-upper arm circumference, stunting, and underweight in communities in the two treatment arms. We were unable to prove that there was a difference in the prevalence of wasting in the 12 communities that received one mass azithromycin distribution versus the 12 communities that received two mass azithromycin distributions (odds ratio = 0.75, 95% confidence interval = 0.46–1.23). Likewise, we were unable to detect a difference in the two treatment arms for low mid-upper arm circumference, stunting, and underweight. There may not be an association between antibiotic use and improved growth in humans, or this trial was not powerful enough to detect an association if it exists.
publisher	The American Society of Tropical Medicine and Hygiene
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541724/
_version_	1611945908876869632

A Cluster-Randomized Controlled Trial Evaluating the Effects of Mass Azithromycin Treatment on Growth and Nutrition in Niger

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