Prime-Boost Immunization of Rabbits with HIV-1 gp120 Elicits Potent Neutralization Activity against a Primary Viral Isolate

Prime-Boost Immunization of Rabbits with HIV-1 gp120 Elicits Potent Neutralization Activity against a Primary Viral Isolate

Development of a vaccine for HIV-1 requires a detailed understanding of the neutralizing antibody responses that can be experimentally elicited to difficult-to-neutralize primary isolates. Rabbits were immunized with the gp120 subunit of HIV-1 JR-CSF envelope (Env) using a DNA-prime protein-boost re...

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Bibliographic Details
Main Authors: Narayan, Kristin M., Agrawal, Nitish, Du, Sean X., Muranaka, Janelle E., Bauer, Katherine, Leaman, Daniel P., Phung, Pham, Limoli, Kay, Chen, Helen, Boenig, Rebecca I., Wrin, Terri, Zwick, Michael B., Whalen, Robert G.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541383/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541383/

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