Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions

Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions

Alzheimer disease (AD) is sometimes referred to as type III diabetes because of the shared risk factors for the two disorders. Insulin resistance, one of the major components of type II diabetes mellitus (T2DM), is a known risk factor for AD. Insulin resistance increases amyloid-β peptide (Aβ) gener...

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Bibliographic Details
Main Authors: Son, Sung Min, Song, Hyundong, Byun, Jayoung, Park, Kyong Soo, Jang, Hak Chul, Park, Young Joo, Mook-Jung, Inhee
Format: Online
Language:English
Published: Landes Bioscience 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541299/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541299/

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