Cadmium Exposure and Pancreatic Cancer in South Louisiana

Cadmium has been hypothesized to be a pancreatic carcinogen. We test the hypothesis that cadmium exposure is a risk factor for pancreatic cancer with a population-based case-control study sampled from a population with persistently high rates of pancreatic cancer (south Louisiana). We tested potenti...

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Main Authors:	Luckett, Brian G., Su, L. Joseph, Rood, Jennifer C., Fontham, Elizabeth T. H.
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540786/

id	pubmed-3540786
recordtype	oai_dc
spelling	pubmed-35407862013-01-14 Cadmium Exposure and Pancreatic Cancer in South Louisiana Luckett, Brian G. Su, L. Joseph Rood, Jennifer C. Fontham, Elizabeth T. H. Research Article Cadmium has been hypothesized to be a pancreatic carcinogen. We test the hypothesis that cadmium exposure is a risk factor for pancreatic cancer with a population-based case-control study sampled from a population with persistently high rates of pancreatic cancer (south Louisiana). We tested potential dietary and nondietary sources of cadmium for their association with urinary cadmium concentrations which reflect long-term exposure to cadmium due to the accumulation of cadmium in the kidney cortex. Increasing urinary cadmium concentrations were significantly associated with an increasing risk of pancreatic cancer (2nd quartile OR = 3.34, 3rd = 5.58, 4th = 7.70; test for trend P ≤ 0.0001). Potential sources of cadmium exposure, as documented in the scientific literature, found to be statistically significantly associated with increased risk of pancreatic cancer included working as a plumber, pipefitter or welder (OR = 5.88) and high consumption levels of red meat (4th quartile OR = 6.18) and grains (4th quartile OR = 3.38). Current cigarette smoking, at least 80 pack years of smoking, occupational exposure to cadmium and paints, working in a shipyard, and high consumption of grains were found to be statistically significantly associated with increased concentrations of urinary cadmium. This study provides epidemiologic evidence that cadmium is a potential human pancreatic carcinogen. Hindawi Publishing Corporation 2012 2012-12-24 /pmc/articles/PMC3540786/ /pubmed/23319964 http://dx.doi.org/10.1155/2012/180186 Text en Copyright © 2012 Brian G. Luckett et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Luckett, Brian G. Su, L. Joseph Rood, Jennifer C. Fontham, Elizabeth T. H.
spellingShingle	Luckett, Brian G. Su, L. Joseph Rood, Jennifer C. Fontham, Elizabeth T. H. Cadmium Exposure and Pancreatic Cancer in South Louisiana
author_facet	Luckett, Brian G. Su, L. Joseph Rood, Jennifer C. Fontham, Elizabeth T. H.
author_sort	Luckett, Brian G.
title	Cadmium Exposure and Pancreatic Cancer in South Louisiana
title_short	Cadmium Exposure and Pancreatic Cancer in South Louisiana
title_full	Cadmium Exposure and Pancreatic Cancer in South Louisiana
title_fullStr	Cadmium Exposure and Pancreatic Cancer in South Louisiana
title_full_unstemmed	Cadmium Exposure and Pancreatic Cancer in South Louisiana
title_sort	cadmium exposure and pancreatic cancer in south louisiana
description	Cadmium has been hypothesized to be a pancreatic carcinogen. We test the hypothesis that cadmium exposure is a risk factor for pancreatic cancer with a population-based case-control study sampled from a population with persistently high rates of pancreatic cancer (south Louisiana). We tested potential dietary and nondietary sources of cadmium for their association with urinary cadmium concentrations which reflect long-term exposure to cadmium due to the accumulation of cadmium in the kidney cortex. Increasing urinary cadmium concentrations were significantly associated with an increasing risk of pancreatic cancer (2nd quartile OR = 3.34, 3rd = 5.58, 4th = 7.70; test for trend P ≤ 0.0001). Potential sources of cadmium exposure, as documented in the scientific literature, found to be statistically significantly associated with increased risk of pancreatic cancer included working as a plumber, pipefitter or welder (OR = 5.88) and high consumption levels of red meat (4th quartile OR = 6.18) and grains (4th quartile OR = 3.38). Current cigarette smoking, at least 80 pack years of smoking, occupational exposure to cadmium and paints, working in a shipyard, and high consumption of grains were found to be statistically significantly associated with increased concentrations of urinary cadmium. This study provides epidemiologic evidence that cadmium is a potential human pancreatic carcinogen.
publisher	Hindawi Publishing Corporation
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540786/
_version_	1611945577876029440

Cadmium Exposure and Pancreatic Cancer in South Louisiana

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