Activation of Peroxisome Proliferator-Activated Receptor γ by Rosiglitazone Inhibits Lipopolysaccharide-Induced Release of High Mobility Group Box 1

Activation of Peroxisome Proliferator-Activated Receptor γ by Rosiglitazone Inhibits Lipopolysaccharide-Induced Release of High Mobility Group Box 1

Peroxisome proliferator-activated receptors (PPARs) are shown to modulate the pathological status of sepsis by regulating the release of high mobility group box 1 (HMGB1), a well-known late proinflammatory mediator of sepsis. Ligand-activated PPARs markedly inhibited lipopolysaccharide- (LPS) induce...

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Bibliographic Details
Main Authors: Hwang, Jung Seok, Kang, Eun Sil, Ham, Sun Ah, Yoo, Taesik, Lee, Hanna, Paek, Kyung Shin, Park, Chankyu, Kim, Jin-Hoi, Lim, Dae-Seog, Seo, Han Geuk
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539392/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539392/

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