Silk fibroin hydrolysate exerts an anti-diabetic effect by increasing pancreatic β cell mass in C57BL/KsJ-db/db mice

Components of silk including silk fibroin have long been used as anti-diabetic remedies in oriental medicine. However, detailed mechanisms underlying these anti-diabetic effects remain unclear. In this study, we examined the anti-diabetic activity of silk fibroin hydrolysate (SFH) in C57BL/KsJ-db/db...

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Main Authors:	Do, Sun-Gil, Park, Jun-Hong, Nam, Hajin, Kim, Jin-Bong, Lee, Jae-Yong, Oh, Yang-Seok, Suh, Jun-Gyo
Format:	Online
Language:	English
Published:	The Korean Society of Veterinary Science 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539118/

id	pubmed-3539118
recordtype	oai_dc
spelling	pubmed-35391182013-01-15 Silk fibroin hydrolysate exerts an anti-diabetic effect by increasing pancreatic β cell mass in C57BL/KsJ-db/db mice Do, Sun-Gil Park, Jun-Hong Nam, Hajin Kim, Jin-Bong Lee, Jae-Yong Oh, Yang-Seok Suh, Jun-Gyo Original Article Components of silk including silk fibroin have long been used as anti-diabetic remedies in oriental medicine. However, detailed mechanisms underlying these anti-diabetic effects remain unclear. In this study, we examined the anti-diabetic activity of silk fibroin hydrolysate (SFH) in C57BL/KsJ-db/db (db/db) mice, a well-known animal model of non-insulin dependent diabetes mellitus. When the db/db mice were administered SFH in drinking water for 6 weeks, hyperglycemia in the animals gradually disappeared and the level of glycosylated hemoglobin decreased, indicating that SFH plays important role in reducing the symptoms of diabetes. In addition, SFH-treated db/db mice exhibited improved glucose tolerance with increased plasma insulin levels. Immunohistochemical and morphological analyses showed that SFH up-regulated insulin production by increasing pancreatic β cell mass in the mice. In summary, our results suggest that SFH exerts anti-diabetic effects by increasing pancreatic β cell mass in a non-insulin dependent diabetes mellitus mouse model. The Korean Society of Veterinary Science 2012-12 2012-12-20 /pmc/articles/PMC3539118/ /pubmed/23271174 http://dx.doi.org/10.4142/jvs.2012.13.4.339 Text en Copyright © 2012 The Korean Society of Veterinary Science http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Do, Sun-Gil Park, Jun-Hong Nam, Hajin Kim, Jin-Bong Lee, Jae-Yong Oh, Yang-Seok Suh, Jun-Gyo
spellingShingle	Do, Sun-Gil Park, Jun-Hong Nam, Hajin Kim, Jin-Bong Lee, Jae-Yong Oh, Yang-Seok Suh, Jun-Gyo Silk fibroin hydrolysate exerts an anti-diabetic effect by increasing pancreatic β cell mass in C57BL/KsJ-db/db mice
author_facet	Do, Sun-Gil Park, Jun-Hong Nam, Hajin Kim, Jin-Bong Lee, Jae-Yong Oh, Yang-Seok Suh, Jun-Gyo
author_sort	Do, Sun-Gil
title	Silk fibroin hydrolysate exerts an anti-diabetic effect by increasing pancreatic β cell mass in C57BL/KsJ-db/db mice
title_short	Silk fibroin hydrolysate exerts an anti-diabetic effect by increasing pancreatic β cell mass in C57BL/KsJ-db/db mice
title_full	Silk fibroin hydrolysate exerts an anti-diabetic effect by increasing pancreatic β cell mass in C57BL/KsJ-db/db mice
title_fullStr	Silk fibroin hydrolysate exerts an anti-diabetic effect by increasing pancreatic β cell mass in C57BL/KsJ-db/db mice
title_full_unstemmed	Silk fibroin hydrolysate exerts an anti-diabetic effect by increasing pancreatic β cell mass in C57BL/KsJ-db/db mice
title_sort	silk fibroin hydrolysate exerts an anti-diabetic effect by increasing pancreatic β cell mass in c57bl/ksj-db/db mice
description	Components of silk including silk fibroin have long been used as anti-diabetic remedies in oriental medicine. However, detailed mechanisms underlying these anti-diabetic effects remain unclear. In this study, we examined the anti-diabetic activity of silk fibroin hydrolysate (SFH) in C57BL/KsJ-db/db (db/db) mice, a well-known animal model of non-insulin dependent diabetes mellitus. When the db/db mice were administered SFH in drinking water for 6 weeks, hyperglycemia in the animals gradually disappeared and the level of glycosylated hemoglobin decreased, indicating that SFH plays important role in reducing the symptoms of diabetes. In addition, SFH-treated db/db mice exhibited improved glucose tolerance with increased plasma insulin levels. Immunohistochemical and morphological analyses showed that SFH up-regulated insulin production by increasing pancreatic β cell mass in the mice. In summary, our results suggest that SFH exerts anti-diabetic effects by increasing pancreatic β cell mass in a non-insulin dependent diabetes mellitus mouse model.
publisher	The Korean Society of Veterinary Science
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539118/
_version_	1611945102895218688

Silk fibroin hydrolysate exerts an anti-diabetic effect by increasing pancreatic β cell mass in C57BL/KsJ-db/db mice

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