Functional In Vivo Delivery of Multiplexed Anti-HIV-1 siRNAs via a Chemically Synthesized Aptamer With a Sticky Bridge

Functional In Vivo Delivery of Multiplexed Anti-HIV-1 siRNAs via a Chemically Synthesized Aptamer With a Sticky Bridge

One of the most formidable impediments to clinical translation of RNA interference (RNAi) is safe and effective delivery of the siRNAs to the desired target tissue at therapeutic doses. We previously described in vivo cell type-specific delivery of anti-HIV small-interfering RNAs (siRNAs) through co...

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Bibliographic Details
Main Authors: Zhou, Jiehua, Neff, C Preston, Swiderski, Piotr, Li, Haitang, Smith, David D, Aboellail, Tawfik, Remling-Mulder, Leila, Akkina, Ramesh, Rossi, John J
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538316/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538316/

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