Synthesis, Antitubercular Activity and Mechanism of Resistance of Highly Effective Thiacetazone Analogues

Defining the pharmacological target(s) of currently used drugs and developing new analogues with greater potency are both important aspects of the search for agents that are effective against drug-sensitive and drug-resistant Mycobacterium tuberculosis. Thiacetazone (TAC) is an anti-tubercular drug...

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Bibliographic Details
Main Authors: Coxon, Geoffrey D., Craig, Derek, Corrales, Rosa Milagros, Vialla, Emilie, Gannoun-Zaki, Laila, Kremer, Laurent
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536773/