Potassium channels in articular chondrocytes
Chondrocytes are the resident cells of cartilage, which synthesize and maintain the extracellular matrix. The range of known potassium channels expressed by these unique cells is continually increasing. Since chondrocytes are non-excitable, and do not need to be repolarized following action potentia...
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Landes Bioscience
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536726/ |
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pubmed-35367262013-01-04 Potassium channels in articular chondrocytes Mobasheri, Ali Lewis, Rebecca Ferreira-Mendes, Alexandrina Rufino, Ana Dart, Caroline Barrett-Jolley, Richard Review Chondrocytes are the resident cells of cartilage, which synthesize and maintain the extracellular matrix. The range of known potassium channels expressed by these unique cells is continually increasing. Since chondrocytes are non-excitable, and do not need to be repolarized following action potentials, the function of potassium channels in these cells has, until recently, remained completely unknown. However, recent advances in both traditional physiology and “omic” technologies have enhanced our knowledge and understanding of the chondrocyte channelome. A large number of potassium channels have been identified and a number of putative, but credible, functions have been proposed. Members of each of the potassium channel sub-families (calcium activated, inward rectifier, voltage-gated and tandem pore) have all been identified. Mechanotransduction, cell volume regulation, apoptosis and chondrogenesis all appear to involve potassium channels. Since evidence suggests that potassium channel gene transcription is altered in osteoarthritis, future studies are needed that investigate potassium channels as potential cellular biomarkers and therapeutic targets for treatment of degenerative joint conditions. Landes Bioscience 2012-11-01 /pmc/articles/PMC3536726/ /pubmed/23064164 http://dx.doi.org/10.4161/chan.22340 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Mobasheri, Ali Lewis, Rebecca Ferreira-Mendes, Alexandrina Rufino, Ana Dart, Caroline Barrett-Jolley, Richard |
| spellingShingle |
Mobasheri, Ali Lewis, Rebecca Ferreira-Mendes, Alexandrina Rufino, Ana Dart, Caroline Barrett-Jolley, Richard Potassium channels in articular chondrocytes |
| author_facet |
Mobasheri, Ali Lewis, Rebecca Ferreira-Mendes, Alexandrina Rufino, Ana Dart, Caroline Barrett-Jolley, Richard |
| author_sort |
Mobasheri, Ali |
| title |
Potassium channels in articular chondrocytes |
| title_short |
Potassium channels in articular chondrocytes |
| title_full |
Potassium channels in articular chondrocytes |
| title_fullStr |
Potassium channels in articular chondrocytes |
| title_full_unstemmed |
Potassium channels in articular chondrocytes |
| title_sort |
potassium channels in articular chondrocytes |
| description |
Chondrocytes are the resident cells of cartilage, which synthesize and maintain the extracellular matrix. The range of known potassium channels expressed by these unique cells is continually increasing. Since chondrocytes are non-excitable, and do not need to be repolarized following action potentials, the function of potassium channels in these cells has, until recently, remained completely unknown. However, recent advances in both traditional physiology and “omic” technologies have enhanced our knowledge and understanding of the chondrocyte channelome. A large number of potassium channels have been identified and a number of putative, but credible, functions have been proposed. Members of each of the potassium channel sub-families (calcium activated, inward rectifier, voltage-gated and tandem pore) have all been identified. Mechanotransduction, cell volume regulation, apoptosis and chondrogenesis all appear to involve potassium channels. Since evidence suggests that potassium channel gene transcription is altered in osteoarthritis, future studies are needed that investigate potassium channels as potential cellular biomarkers and therapeutic targets for treatment of degenerative joint conditions. |
| publisher |
Landes Bioscience |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536726/ |
| _version_ |
1611944528258793472 |