Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses

Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses

Several pharmacological agents acting on monoamine neurotransmission are used for the management of mental illnesses. Regulation of PI3K/AKT and GSK3 pathways may constitute an important signaling center in the subcellular integration of the synaptic neurotransmission. The pathways also modulate neu...

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Main Authors: Kitagishi, Yasuko, Kobayashi, Mayumi, Kikuta, Kanae, Matsuda, Satoru
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535741/
id pubmed-3535741
recordtype oai_dc
spelling pubmed-35357412013-01-14 Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses Kitagishi, Yasuko Kobayashi, Mayumi Kikuta, Kanae Matsuda, Satoru Review Article Several pharmacological agents acting on monoamine neurotransmission are used for the management of mental illnesses. Regulation of PI3K/AKT and GSK3 pathways may constitute an important signaling center in the subcellular integration of the synaptic neurotransmission. The pathways also modulate neuronal cell proliferation, migration, and plasticity. There are evidences to suggest that inflammation of neuron contributes to the pathology of depression. Inflammatory activation of neuron contributes to the loss of glial elements, which are consistent with pathological findings characterizing the depression. A mechanism of anti-inflammatory reactions from antidepressant medications has been found to be associated with an enhancement of heme oxygenase-1 expression. This induction in brain is also important in neuroprotection and neuroplasticity. As enzymes involved in cell survival and neuroplasticity are relevant to neurotrophic factor dysregulation, the PI3K/AKT/GSK3 may provide an important signaling for the neuroprotection in depression. In this paper, we summarize advances on the involvement of the PI3K/AKT/GSK3 pathways in cell signaling of neuronal cells in mental illnesses. Hindawi Publishing Corporation 2012 2012-12-18 /pmc/articles/PMC3535741/ /pubmed/23320155 http://dx.doi.org/10.1155/2012/752563 Text en Copyright © 2012 Yasuko Kitagishi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Kitagishi, Yasuko
Kobayashi, Mayumi
Kikuta, Kanae
Matsuda, Satoru
spellingShingle Kitagishi, Yasuko
Kobayashi, Mayumi
Kikuta, Kanae
Matsuda, Satoru
Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses
author_facet Kitagishi, Yasuko
Kobayashi, Mayumi
Kikuta, Kanae
Matsuda, Satoru
author_sort Kitagishi, Yasuko
title Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses
title_short Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses
title_full Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses
title_fullStr Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses
title_full_unstemmed Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses
title_sort roles of pi3k/akt/gsk3/mtor pathway in cell signaling of mental illnesses
description Several pharmacological agents acting on monoamine neurotransmission are used for the management of mental illnesses. Regulation of PI3K/AKT and GSK3 pathways may constitute an important signaling center in the subcellular integration of the synaptic neurotransmission. The pathways also modulate neuronal cell proliferation, migration, and plasticity. There are evidences to suggest that inflammation of neuron contributes to the pathology of depression. Inflammatory activation of neuron contributes to the loss of glial elements, which are consistent with pathological findings characterizing the depression. A mechanism of anti-inflammatory reactions from antidepressant medications has been found to be associated with an enhancement of heme oxygenase-1 expression. This induction in brain is also important in neuroprotection and neuroplasticity. As enzymes involved in cell survival and neuroplasticity are relevant to neurotrophic factor dysregulation, the PI3K/AKT/GSK3 may provide an important signaling for the neuroprotection in depression. In this paper, we summarize advances on the involvement of the PI3K/AKT/GSK3 pathways in cell signaling of neuronal cells in mental illnesses.
publisher Hindawi Publishing Corporation
publishDate 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535741/
_version_ 1611944339201589248

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