Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex

Impairment of reciprocal social interaction is a core symptom of autism spectrum disorder. Genetic disorders frequently accompany autism spectrum disorder, such as tuberous sclerosis complex caused by haploinsufficiency of the TSC1 and TSC2 genes. Accumulating evidence implicates a relationship betw...

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Bibliographic Details
Main Authors: Sato, Atsushi, Kasai, Shinya, Kobayashi, Toshiyuki, Takamatsu, Yukio, Hino, Okio, Ikeda, Kazutaka, Mizuguchi, Masashi
Format: Online
Language:English
Published: Nature Pub. Group 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535343/