Spleen-Derived Interleukin-10 Downregulates the Severity of High-Fat Diet-Induced Non-Alcoholic Fatty Pancreas Disease

Spleen-Derived Interleukin-10 Downregulates the Severity of High-Fat Diet-Induced Non-Alcoholic Fatty Pancreas Disease

Obesity is associated with systemic low-grade inflammation and is a risk factor for non-alcoholic fatty pancreas disease (NAFPD), but the molecular mechanisms of these associations are not clear. Interleukin (IL)-10, a potent anti-inflammatory cytokine, is released during acute pancreatitis and is k...

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Bibliographic Details
Main Authors: Gotoh, Koro, Inoue, Megumi, Shiraishi, Kentaro, Masaki, Takayuki, Chiba, Seiichi, Mitsutomi, Kimihiko, Shimasaki, Takanobu, Ando, Hisae, Fujiwara, Kansuke, Katsuragi, Isao, Kakuma, Tetsuya, Seike, Masataka, Sakata, Toshiie, Yoshimatsu, Hironobu
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532347/

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