LncRNADisease: a database for long-non-coding RNA-associated diseases

In this article, we describe a long-non-coding RNA (lncRNA) and disease association database (LncRNADisease), which is publicly accessible at http://cmbi.bjmu.edu.cn/lncrnadisease. In recent years, a large number of lncRNAs have been identified and increasing evidence shows that lncRNAs play critica...

Full description

Bibliographic Details
Main Authors:	Chen, Geng, Wang, Ziyun, Wang, Dongqing, Qiu, Chengxiang, Liu, Mingxi, Chen, Xing, Zhang, Qipeng, Yan, Guiying, Cui, Qinghua
Format:	Online
Language:	English
Published:	Oxford University Press 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531173/

id	pubmed-3531173
recordtype	oai_dc
spelling	pubmed-35311732013-01-03 LncRNADisease: a database for long-non-coding RNA-associated diseases Chen, Geng Wang, Ziyun Wang, Dongqing Qiu, Chengxiang Liu, Mingxi Chen, Xing Zhang, Qipeng Yan, Guiying Cui, Qinghua Articles In this article, we describe a long-non-coding RNA (lncRNA) and disease association database (LncRNADisease), which is publicly accessible at http://cmbi.bjmu.edu.cn/lncrnadisease. In recent years, a large number of lncRNAs have been identified and increasing evidence shows that lncRNAs play critical roles in various biological processes. Therefore, the dysfunctions of lncRNAs are associated with a wide range of diseases. It thus becomes important to understand lncRNAs’ roles in diseases and to identify candidate lncRNAs for disease diagnosis, treatment and prognosis. For this purpose, a high-quality lncRNA–disease association database would be extremely beneficial. Here, we describe the LncRNADisease database that collected and curated approximately 480 entries of experimentally supported lncRNA–disease associations, including 166 diseases. LncRNADisease also curated 478 entries of lncRNA interacting partners at various molecular levels, including protein, RNA, miRNA and DNA. Moreover, we annotated lncRNA–disease associations with genomic information, sequences, references and species. We normalized the disease name and the type of lncRNA dysfunction and provided a detailed description for each entry. Finally, we developed a bioinformatic method to predict novel lncRNA–disease associations and integrated the method and the predicted associated diseases of 1564 human lncRNAs into the database. Oxford University Press 2013-01 2012-11-21 /pmc/articles/PMC3531173/ /pubmed/23175614 http://dx.doi.org/10.1093/nar/gks1099 Text en © The Author(s) 2012. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Chen, Geng Wang, Ziyun Wang, Dongqing Qiu, Chengxiang Liu, Mingxi Chen, Xing Zhang, Qipeng Yan, Guiying Cui, Qinghua
spellingShingle	Chen, Geng Wang, Ziyun Wang, Dongqing Qiu, Chengxiang Liu, Mingxi Chen, Xing Zhang, Qipeng Yan, Guiying Cui, Qinghua LncRNADisease: a database for long-non-coding RNA-associated diseases
author_facet	Chen, Geng Wang, Ziyun Wang, Dongqing Qiu, Chengxiang Liu, Mingxi Chen, Xing Zhang, Qipeng Yan, Guiying Cui, Qinghua
author_sort	Chen, Geng
title	LncRNADisease: a database for long-non-coding RNA-associated diseases
title_short	LncRNADisease: a database for long-non-coding RNA-associated diseases
title_full	LncRNADisease: a database for long-non-coding RNA-associated diseases
title_fullStr	LncRNADisease: a database for long-non-coding RNA-associated diseases
title_full_unstemmed	LncRNADisease: a database for long-non-coding RNA-associated diseases
title_sort	lncrnadisease: a database for long-non-coding rna-associated diseases
description	In this article, we describe a long-non-coding RNA (lncRNA) and disease association database (LncRNADisease), which is publicly accessible at http://cmbi.bjmu.edu.cn/lncrnadisease. In recent years, a large number of lncRNAs have been identified and increasing evidence shows that lncRNAs play critical roles in various biological processes. Therefore, the dysfunctions of lncRNAs are associated with a wide range of diseases. It thus becomes important to understand lncRNAs’ roles in diseases and to identify candidate lncRNAs for disease diagnosis, treatment and prognosis. For this purpose, a high-quality lncRNA–disease association database would be extremely beneficial. Here, we describe the LncRNADisease database that collected and curated approximately 480 entries of experimentally supported lncRNA–disease associations, including 166 diseases. LncRNADisease also curated 478 entries of lncRNA interacting partners at various molecular levels, including protein, RNA, miRNA and DNA. Moreover, we annotated lncRNA–disease associations with genomic information, sequences, references and species. We normalized the disease name and the type of lncRNA dysfunction and provided a detailed description for each entry. Finally, we developed a bioinformatic method to predict novel lncRNA–disease associations and integrated the method and the predicted associated diseases of 1564 human lncRNAs into the database.
publisher	Oxford University Press
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531173/
_version_	1611942998764945408

LncRNADisease: a database for long-non-coding RNA-associated diseases

Similar Items