A glutamate switch controls voltage-sensitive phosphatase function

A glutamate switch controls voltage-sensitive phosphatase function

Ciona intestinalis voltage sensing phosphatase Ci-VSP couples a voltage-sensing domain (VSD) to a lipid phosphatase similar to the tumor suppressor PTEN. How the VSD controls enzyme function has been unclear. Here, we present high-resolution crystal structures of the Ci-VSP enzymatic domain that rev...

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Bibliographic Details
Main Authors: Liu, Lijun, Kohout, Susy C., Xu, Qiang, Müller, Simone, Kimberlin, Christopher R., Isacoff, Ehud Y., Minor, Daniel L.
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529583/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529583/

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