Cholesterol Modulates Cell Signaling and Protein Networking by Specifically Interacting with PDZ Domain-Containing Scaffold Proteins

Cholesterol Modulates Cell Signaling and Protein Networking by Specifically Interacting with PDZ Domain-Containing Scaffold Proteins

Cholesterol is known to modulate the physical properties of cell membranes but its direct involvement in cellular signaling has not been thoroughly investigated. Here we show that cholesterol specifically binds many PDZ domains found in scaffold proteins, including the N-terminal PDZ domain of NHERF...

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Bibliographic Details
Main Authors: Sheng, Ren, Chen, Yong, Gee, Heon Yung, Stec, Ewa, Melowic, Heather R., Blatner, Nichole R., Tun, Moe P., Kim, Yonjung, Källberg, Morten, Fujiwara, Takahiro K., Hong, Ji Hye, Kim, Kwang Pyo, Lu, Hui, Kusumi, Akihiro, Lee, Min Goo, Cho, Wonhwa
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526836/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526836/

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