The luminal Ca2+ chelator, TPEN, inhibits NAADP-induced Ca2+ release

The regulation of Ca2+ release by luminal Ca2+ has been well studied for the ryanodine and IP3 receptors but has been less clear for the NAADP-regulated channel. In view of conflicting reports, we have re-examined the issue by manipulating luminal Ca2+ with the membrane-permeant, low affinity Ca2+ b...

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Bibliographic Details
Main Authors: Morgan, Anthony J., Parrington, John, Galione, Antony
Format: Online
Language:English
Published: Elsevier 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526783/