Biocompatible nanocomposite for PET/MRI hybrid imaging

Biocompatible nanocomposite for PET/MRI hybrid imaging

A novel nanocarrier system was designed and developed with key components uniquely structured at the nanoscale for early cancer diagnosis and treatment. In order to perform magnetic resonance imaging, hydrophilic superparamagnetic maghemite nanoparticles (NPs) were synthesized and coated with a lipo...

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Main Authors: Locatelli, Erica, Gil, Larraitz, Israel, Liron Limor, Passoni, Lorena, Naddaka, Maria, Pucci, Andrea, Reese, Torsten, Gomez-Vallejo, Vanessa, Milani, Paolo, Matteoli, Michela, Llop, Jordi, Lellouche, Jean Paul, Franchini, Mauro Comes
Format: Online
Language:English
Published: Dove Medical Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526150/
id pubmed-3526150
recordtype oai_dc
spelling pubmed-35261502012-12-27 Biocompatible nanocomposite for PET/MRI hybrid imaging Locatelli, Erica Gil, Larraitz Israel, Liron Limor Passoni, Lorena Naddaka, Maria Pucci, Andrea Reese, Torsten Gomez-Vallejo, Vanessa Milani, Paolo Matteoli, Michela Llop, Jordi Lellouche, Jean Paul Franchini, Mauro Comes Original Research A novel nanocarrier system was designed and developed with key components uniquely structured at the nanoscale for early cancer diagnosis and treatment. In order to perform magnetic resonance imaging, hydrophilic superparamagnetic maghemite nanoparticles (NPs) were synthesized and coated with a lipophilic organic ligand. Next, they were entrapped into polymeric NPs made of biodegradable poly(lactic-co-glycolic acid) linked to polyethylene glycol. In addition, resulting NPs have been conjugated on their surface with a 2,2′-(7-(4-((2-aminoethyl)amino)-1-carboxy-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid ligand for subsequent 68Ga incorporation. A cell-based cytotoxicity assay has been employed to verify the in vitro cell viability of human pancreatic cancer cells exposed to this nanosystem. Finally, in vivo positron emission tomography-computerized tomography biodistribution studies in healthy animals were performed. Dove Medical Press 2012 2012-12-12 /pmc/articles/PMC3526150/ /pubmed/23271907 http://dx.doi.org/10.2147/IJN.S38107 Text en © 2012 Locatelli et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Locatelli, Erica
Gil, Larraitz
Israel, Liron Limor
Passoni, Lorena
Naddaka, Maria
Pucci, Andrea
Reese, Torsten
Gomez-Vallejo, Vanessa
Milani, Paolo
Matteoli, Michela
Llop, Jordi
Lellouche, Jean Paul
Franchini, Mauro Comes
spellingShingle Locatelli, Erica
Gil, Larraitz
Israel, Liron Limor
Passoni, Lorena
Naddaka, Maria
Pucci, Andrea
Reese, Torsten
Gomez-Vallejo, Vanessa
Milani, Paolo
Matteoli, Michela
Llop, Jordi
Lellouche, Jean Paul
Franchini, Mauro Comes
Biocompatible nanocomposite for PET/MRI hybrid imaging
author_facet Locatelli, Erica
Gil, Larraitz
Israel, Liron Limor
Passoni, Lorena
Naddaka, Maria
Pucci, Andrea
Reese, Torsten
Gomez-Vallejo, Vanessa
Milani, Paolo
Matteoli, Michela
Llop, Jordi
Lellouche, Jean Paul
Franchini, Mauro Comes
author_sort Locatelli, Erica
title Biocompatible nanocomposite for PET/MRI hybrid imaging
title_short Biocompatible nanocomposite for PET/MRI hybrid imaging
title_full Biocompatible nanocomposite for PET/MRI hybrid imaging
title_fullStr Biocompatible nanocomposite for PET/MRI hybrid imaging
title_full_unstemmed Biocompatible nanocomposite for PET/MRI hybrid imaging
title_sort biocompatible nanocomposite for pet/mri hybrid imaging
description A novel nanocarrier system was designed and developed with key components uniquely structured at the nanoscale for early cancer diagnosis and treatment. In order to perform magnetic resonance imaging, hydrophilic superparamagnetic maghemite nanoparticles (NPs) were synthesized and coated with a lipophilic organic ligand. Next, they were entrapped into polymeric NPs made of biodegradable poly(lactic-co-glycolic acid) linked to polyethylene glycol. In addition, resulting NPs have been conjugated on their surface with a 2,2′-(7-(4-((2-aminoethyl)amino)-1-carboxy-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid ligand for subsequent 68Ga incorporation. A cell-based cytotoxicity assay has been employed to verify the in vitro cell viability of human pancreatic cancer cells exposed to this nanosystem. Finally, in vivo positron emission tomography-computerized tomography biodistribution studies in healthy animals were performed.
publisher Dove Medical Press
publishDate 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526150/
_version_ 1611941549023690752

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