The promise of the anti-idiotype concept

A basic tenet of antibody-based immunity is their specificity to antigenic determinates from foreign pathogen products to abnormal cellular components such as in cancer. However, an antibody has the potential to bind to more than one determinate, be it an antigen or another antibody. These observati...

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Main Authors:	Kieber-Emmons, Thomas, Monzavi-Karbassi, Bejatohlah, Pashov, Anastas, Saha, Somdutta, Murali, Ramachandran, Kohler, Heinz
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526099/

id	pubmed-3526099
recordtype	oai_dc
spelling	pubmed-35260992012-12-24 The promise of the anti-idiotype concept Kieber-Emmons, Thomas Monzavi-Karbassi, Bejatohlah Pashov, Anastas Saha, Somdutta Murali, Ramachandran Kohler, Heinz Immunology A basic tenet of antibody-based immunity is their specificity to antigenic determinates from foreign pathogen products to abnormal cellular components such as in cancer. However, an antibody has the potential to bind to more than one determinate, be it an antigen or another antibody. These observations led to the idiotype network theory (INT) to explain immune regulation, which has wax and waned in enthusiasm over the years. A truer measure of the impact of the INT is in terms of the ideas that now form the mainstay of immunological research and whose roots are spawned from the promise of the anti-idiotype concept. Among the applications of the INT is understanding the structural implications of the antibody-mediated network that has the potential for innovation in terms of rational design of reagents with biological, chemical, and pharmaceutical applications that underlies concepts of reverse immunology which is highlighted herein. Frontiers Media S.A. 2012-12-19 /pmc/articles/PMC3526099/ /pubmed/23267437 http://dx.doi.org/10.3389/fonc.2012.00196 Text en Copyright © Kieber-Emmons, Monzavi-Karbassi, Pashov, Saha, Murali and Kohler. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kieber-Emmons, Thomas Monzavi-Karbassi, Bejatohlah Pashov, Anastas Saha, Somdutta Murali, Ramachandran Kohler, Heinz
spellingShingle	Kieber-Emmons, Thomas Monzavi-Karbassi, Bejatohlah Pashov, Anastas Saha, Somdutta Murali, Ramachandran Kohler, Heinz The promise of the anti-idiotype concept
author_facet	Kieber-Emmons, Thomas Monzavi-Karbassi, Bejatohlah Pashov, Anastas Saha, Somdutta Murali, Ramachandran Kohler, Heinz
author_sort	Kieber-Emmons, Thomas
title	The promise of the anti-idiotype concept
title_short	The promise of the anti-idiotype concept
title_full	The promise of the anti-idiotype concept
title_fullStr	The promise of the anti-idiotype concept
title_full_unstemmed	The promise of the anti-idiotype concept
title_sort	promise of the anti-idiotype concept
description	A basic tenet of antibody-based immunity is their specificity to antigenic determinates from foreign pathogen products to abnormal cellular components such as in cancer. However, an antibody has the potential to bind to more than one determinate, be it an antigen or another antibody. These observations led to the idiotype network theory (INT) to explain immune regulation, which has wax and waned in enthusiasm over the years. A truer measure of the impact of the INT is in terms of the ideas that now form the mainstay of immunological research and whose roots are spawned from the promise of the anti-idiotype concept. Among the applications of the INT is understanding the structural implications of the antibody-mediated network that has the potential for innovation in terms of rational design of reagents with biological, chemical, and pharmaceutical applications that underlies concepts of reverse immunology which is highlighted herein.
publisher	Frontiers Media S.A.
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526099/
_version_	1611941532016836608

The promise of the anti-idiotype concept

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