Autocrine Function of Aldehyde Dehydrogenase 1 as a Determinant of Diet- and Sex-Specific Differences in Visceral Adiposity

Autocrine Function of Aldehyde Dehydrogenase 1 as a Determinant of Diet- and Sex-Specific Differences in Visceral Adiposity

Mechanisms for sex- and depot-specific fat formation are unclear. We investigated the role of retinoic acid (RA) production by aldehyde dehydrogenase 1 (Aldh1a1, -a2, and -a3), the major RA-producing enzymes, on sex-specific fat depot formation. Female Aldh1a1−/− mice, but not males, were resistant...

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Main Authors: Yasmeen, Rumana, Reichert, Barbara, Deiuliis, Jeffrey, Yang, Fangping, Lynch, Alisha, Meyers, Joseph, Sharlach, Molly, Shin, Sangsu, Volz, Katharina S., Green, Kari B., Lee, Kichoon, Alder, Hansjuerg, Duester, Gregg, Zechner, Rudolf, Rajagopalan, Sanjay, Ziouzenkova, Ouliana
Format: Online
Language:English
Published: American Diabetes Association 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526050/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526050/

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