Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects

Retrospective clinical data indicate that cardiac glycosides (CGs), notably digoxin, prolong the survival of carcinoma patients treated with conventional chemotherapy. CGs are known to influence the immune response at multiple levels. In addition, recent results suggest that CGs trigger the immunoge...

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Main Authors:	Kepp, Oliver, Menger, Laurie, Vacchelli, Erika, Adjemian, Sandy, Martins, Isabelle, Ma, Yuting, Sukkurwala, Abdul Qader, Michaud, Mickaël, Galluzzi, Lorenzo, Zitvogel, Laurence, Kroemer, Guido
Format:	Online
Language:	English
Published:	Landes Bioscience 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525630/

id	pubmed-3525630
recordtype	oai_dc
spelling	pubmed-35256302012-12-21 Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects Kepp, Oliver Menger, Laurie Vacchelli, Erika Adjemian, Sandy Martins, Isabelle Ma, Yuting Sukkurwala, Abdul Qader Michaud, Mickaël Galluzzi, Lorenzo Zitvogel, Laurence Kroemer, Guido Author's View Retrospective clinical data indicate that cardiac glycosides (CGs), notably digoxin, prolong the survival of carcinoma patients treated with conventional chemotherapy. CGs are known to influence the immune response at multiple levels. In addition, recent results suggest that CGs trigger the immunogenic demise of cancer cells, an effect that most likely contributes to their clinical anticancer activity. Landes Bioscience 2012-12-01 /pmc/articles/PMC3525630/ /pubmed/23264921 http://dx.doi.org/10.4161/onci.21684 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kepp, Oliver Menger, Laurie Vacchelli, Erika Adjemian, Sandy Martins, Isabelle Ma, Yuting Sukkurwala, Abdul Qader Michaud, Mickaël Galluzzi, Lorenzo Zitvogel, Laurence Kroemer, Guido
spellingShingle	Kepp, Oliver Menger, Laurie Vacchelli, Erika Adjemian, Sandy Martins, Isabelle Ma, Yuting Sukkurwala, Abdul Qader Michaud, Mickaël Galluzzi, Lorenzo Zitvogel, Laurence Kroemer, Guido Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects
author_facet	Kepp, Oliver Menger, Laurie Vacchelli, Erika Adjemian, Sandy Martins, Isabelle Ma, Yuting Sukkurwala, Abdul Qader Michaud, Mickaël Galluzzi, Lorenzo Zitvogel, Laurence Kroemer, Guido
author_sort	Kepp, Oliver
title	Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects
title_short	Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects
title_full	Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects
title_fullStr	Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects
title_full_unstemmed	Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects
title_sort	anticancer activity of cardiac glycosides: at the frontier between cell-autonomous and immunological effects
description	Retrospective clinical data indicate that cardiac glycosides (CGs), notably digoxin, prolong the survival of carcinoma patients treated with conventional chemotherapy. CGs are known to influence the immune response at multiple levels. In addition, recent results suggest that CGs trigger the immunogenic demise of cancer cells, an effect that most likely contributes to their clinical anticancer activity.
publisher	Landes Bioscience
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525630/
_version_	1611941402815496192

Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects

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