Influence of SLCO1B1 and CYP2C8 gene polymorphisms on rosiglitazone pharmacokinetics in healthy volunteers

Influence of SLCO1B1 and CYP2C8 gene polymorphisms on rosiglitazone pharmacokinetics in healthy volunteers

Polymorphisms in drug transporter genes and/or drug-metabolising enzyme genes may contribute to inter-individual variability in rosiglitazone pharmacokinetics in humans. We sought to determine the joint effects of polymorphisms in the SLCO1B1 drug transporter gene and the cytochrome P450 (CYP) 2C8-m...

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Bibliographic Details
Main Authors: Aquilante, Christina L, Bushman, Lane R, Knutsen, Shannon D, Burt, Lauren E, Rome, Lucille Capo, Kosmiski, Lisa A
Format: Online
Language:English
Published: BioMed Central 2008
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525178/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525178/

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