Immunization with a Recombinant Vaccinia Virus That Encodes Nonstructural Proteins of the Hepatitis C Virus Suppresses Viral Protein Levels in Mouse Liver

Immunization with a Recombinant Vaccinia Virus That Encodes Nonstructural Proteins of the Hepatitis C Virus Suppresses Viral Protein Levels in Mouse Liver

Chronic hepatitis C, which is caused by infection with the hepatitis C virus (HCV), is a global health problem. Using a mouse model of hepatitis C, we examined the therapeutic effects of a recombinant vaccinia virus (rVV) that encodes an HCV protein. We generated immunocompetent mice that each expre...

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Bibliographic Details
Main Authors: Sekiguchi, Satoshi, Kimura, Kiminori, Chiyo, Tomoko, Ohtsuki, Takahiro, Tobita, Yoshimi, Tokunaga, Yuko, Yasui, Fumihiko, Tsukiyama-Kohara, Kyoko, Wakita, Takaji, Tanaka, Toshiyuki, Miyasaka, Masayuki, Mizuno, Kyosuke, Hayashi, Yukiko, Hishima, Tsunekazu, Matsushima, Kouji, Kohara, Michinori
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524174/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524174/

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