The Relationship between Aggregation and Toxicity of Polyglutamine-Containing Ataxin-3 in the Intracellular Environment of Escherichia coli

The Relationship between Aggregation and Toxicity of Polyglutamine-Containing Ataxin-3 in the Intracellular Environment of Escherichia coli

Several neurodegenerative diseases are triggered by proteins containing a polyglutamine (polyQ) stretch expanded beyond a critical threshold. Among these, ataxin-3 (AT3) is the causative agent of spinocerebellar ataxia type-3. We expressed three authentic AT3 variants in Escherichia coli: one normal...

Full description

Bibliographic Details
Main Authors: Invernizzi, Gaetano, Aprile, Francesco A., Natalello, Antonino, Ghisleni, Andrea, Penco, Amanda, Relini, Annalisa, Doglia, Silvia M., Tortora, Paolo, Regonesi, Maria E.
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522584/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522584/

Similar Items