The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle
The N-terminus of the kinesin-13 family (Kif2a, Kif2b, Kif2c) is the primary localization determinant. However, the C-terminus of Kif2b associates with Cep170 and Cep170R to create targeting specificity. Cep170 has microtubule-binding properties in vitro and provides a second microtubule-binding sit...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521686/ |