Utilizing the folate receptor for active targeting of cancer nanotherapeutics
The development of specialized nanoparticles for use in the detection and treatment of cancer is increasing. Methods are being proposed and tested that could target treatments more directly to cancer cells, which could lead to higher efficacy and reduced toxicity, possibly even eliminating the adver...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Co-Action Publishing
2012
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521101/ |
| id |
pubmed-3521101 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-35211012012-12-13 Utilizing the folate receptor for active targeting of cancer nanotherapeutics Zwicke, Grant L. Mansoori, G. Ali Jeffery, Constance J. Mini-Review The development of specialized nanoparticles for use in the detection and treatment of cancer is increasing. Methods are being proposed and tested that could target treatments more directly to cancer cells, which could lead to higher efficacy and reduced toxicity, possibly even eliminating the adverse effects of damage to the immune system and the loss of quick replicating cells. In this mini-review we focus on recent studies that employ folate nanoconjugates to target the folate receptor. Folate receptors are highly overexpressed on the surface of many tumor types. This expression can be exploited to target imaging molecules and therapeutic compounds directly to cancerous tissues. Co-Action Publishing 2012-12-07 /pmc/articles/PMC3521101/ /pubmed/23240070 http://dx.doi.org/10.3402/nano.v3i0.18496 Text en © 2012 Grant L. Zwicke et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Zwicke, Grant L. Mansoori, G. Ali Jeffery, Constance J. |
| spellingShingle |
Zwicke, Grant L. Mansoori, G. Ali Jeffery, Constance J. Utilizing the folate receptor for active targeting of cancer nanotherapeutics |
| author_facet |
Zwicke, Grant L. Mansoori, G. Ali Jeffery, Constance J. |
| author_sort |
Zwicke, Grant L. |
| title |
Utilizing the folate receptor for active targeting of cancer nanotherapeutics |
| title_short |
Utilizing the folate receptor for active targeting of cancer nanotherapeutics |
| title_full |
Utilizing the folate receptor for active targeting of cancer nanotherapeutics |
| title_fullStr |
Utilizing the folate receptor for active targeting of cancer nanotherapeutics |
| title_full_unstemmed |
Utilizing the folate receptor for active targeting of cancer nanotherapeutics |
| title_sort |
utilizing the folate receptor for active targeting of cancer nanotherapeutics |
| description |
The development of specialized nanoparticles for use in the detection and treatment of cancer is increasing. Methods are being proposed and tested that could target treatments more directly to cancer cells, which could lead to higher efficacy and reduced toxicity, possibly even eliminating the adverse effects of damage to the immune system and the loss of quick replicating cells. In this mini-review we focus on recent studies that employ folate nanoconjugates to target the folate receptor. Folate receptors are highly overexpressed on the surface of many tumor types. This expression can be exploited to target imaging molecules and therapeutic compounds directly to cancerous tissues. |
| publisher |
Co-Action Publishing |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521101/ |
| _version_ |
1611940047310815232 |