Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses
The use of adenovirus serotype 5 (Ad5) vectors in the clinical setting is severely hampered by the profound liver tropism observed after intravascular delivery coupled with the pronounced inflammatory and innate immune response elicited by these vectors. Liver transduction by circulating Ad5 virions...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Elsevier Science Publishers
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520007/ |