Leukemia Cutis

Leukemia Cutis

Leukemia cutis is the infiltration of neoplastic leukocytes or their precursors into the epidermis, the dermis, or the subcutis, resulting in clinically identifiable cutaneous lesions. Leukemia cutis may follow, precede or occur concomitantly with the diagnosis of systemic leukemia. A 50-year-old wo...

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Main Authors: Rao, Angoori G, Danturty, Indira
Format: Online
Language:English
Published: Medknow Publications & Media Pvt Ltd 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519272/
id pubmed-3519272
recordtype oai_dc
spelling pubmed-35192722012-12-17 Leukemia Cutis Rao, Angoori G Danturty, Indira E–Case Report Leukemia cutis is the infiltration of neoplastic leukocytes or their precursors into the epidermis, the dermis, or the subcutis, resulting in clinically identifiable cutaneous lesions. Leukemia cutis may follow, precede or occur concomitantly with the diagnosis of systemic leukemia. A 50-year-old woman presented with asymptomatic multiple cutaneous nodules all over the body of 4 months duration. Cutaneous examination showed multiple hyperpigmented nodules and plaques involving face, trunk, and extremities. Peripheral smear showed abnormally elevated leucocyte count (TLC-70,000) with abnormal cells: myeloblasts 40%, promyelocytes 8% and myelocytes 39%. Auer rods were present in few myeloblasts. Bone marrow aspiration showed increased cellularity, erythroid hyperplasia with megaloblastic change, increased myeloblasts with maturation arrest. Immunohistochemistry showed strongly positive myeloperoxidase infiltrating cells and negative for CD20 and CD3 consistent with the diagnosis of AML–M 2 with leukemia cutis. This case is reported for its rarity. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3519272/ /pubmed/23248383 http://dx.doi.org/10.4103/0019-5154.103086 Text en Copyright: © Indian Journal of Dermatology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Rao, Angoori G
Danturty, Indira
spellingShingle Rao, Angoori G
Danturty, Indira
Leukemia Cutis
author_facet Rao, Angoori G
Danturty, Indira
author_sort Rao, Angoori G
title Leukemia Cutis
title_short Leukemia Cutis
title_full Leukemia Cutis
title_fullStr Leukemia Cutis
title_full_unstemmed Leukemia Cutis
title_sort leukemia cutis
description Leukemia cutis is the infiltration of neoplastic leukocytes or their precursors into the epidermis, the dermis, or the subcutis, resulting in clinically identifiable cutaneous lesions. Leukemia cutis may follow, precede or occur concomitantly with the diagnosis of systemic leukemia. A 50-year-old woman presented with asymptomatic multiple cutaneous nodules all over the body of 4 months duration. Cutaneous examination showed multiple hyperpigmented nodules and plaques involving face, trunk, and extremities. Peripheral smear showed abnormally elevated leucocyte count (TLC-70,000) with abnormal cells: myeloblasts 40%, promyelocytes 8% and myelocytes 39%. Auer rods were present in few myeloblasts. Bone marrow aspiration showed increased cellularity, erythroid hyperplasia with megaloblastic change, increased myeloblasts with maturation arrest. Immunohistochemistry showed strongly positive myeloperoxidase infiltrating cells and negative for CD20 and CD3 consistent with the diagnosis of AML–M 2 with leukemia cutis. This case is reported for its rarity.
publisher Medknow Publications & Media Pvt Ltd
publishDate 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519272/
_version_ 1611939489748353024

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