The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

Highwire, a conserved axonal E3 ubiquitin ligase, regulates the initiation of axonal degeneration after injury in Drosophila by regulating the levels of the NAD+ biosynthetic enzyme, Nmnat, and the Wnd kinase.

Bibliographic Details
Main Authors: Xiong, Xin, Hao, Yan, Sun, Kan, Li, Jiaxing, Li, Xia, Mishra, Bibhudatta, Soppina, Pushpanjali, Wu, Chunlai, Hume, Richard I., Collins, Catherine A.
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514318/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514318/

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