Immunotherapy of Tumors with α2-Macroglobulin-Antigen Complexes Pre-Formed In Vivo
The cell surface receptor CD91/LRP-1 binds to immunogenic heat shock proteins (HSP) and α2M ligands to elicit T cell immune responses. In order to generate specific immune responses, the peptides chaperoned by HSPs or α2M are cross-presented on MHC molecules to T cells. While the immunogenic HSPs na...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Public Library of Science
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511516/ |