Sleep Loss and Cytokines Levels in an Experimental Model of Psoriasis

Up to 80% of people develop a cutaneous condition closely connected to their exposure to stressful life events. Psoriasis is a chronic recurrent inflammatory skin disorder with multifactorial etiology, including genetic background, environmental factors, and immune system disturbances with a strong...

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Main Authors:	Hirotsu, Camila, Rydlewski, Mariana, Araújo, Mariana Silva, Tufik, Sergio, Andersen, Monica Levy
Format:	Online
Language:	English
Published:	Public Library of Science 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511390/

id	pubmed-3511390
recordtype	oai_dc
spelling	pubmed-35113902012-12-05 Sleep Loss and Cytokines Levels in an Experimental Model of Psoriasis Hirotsu, Camila Rydlewski, Mariana Araújo, Mariana Silva Tufik, Sergio Andersen, Monica Levy Research Article Up to 80% of people develop a cutaneous condition closely connected to their exposure to stressful life events. Psoriasis is a chronic recurrent inflammatory skin disorder with multifactorial etiology, including genetic background, environmental factors, and immune system disturbances with a strong cytokine component. Moreover, psoriasis is variably associated with sleep disturbance and sleep deprivation. This study evaluated the influence of sleep loss in the context of an animal model of psoriasis by measuring cytokine and stress-related hormone levels. Male adult Balb/C mice with or without psoriasis were subjected to 48 h of selective paradoxical sleep deprivation (PSD). Sleep deprivation potentiated the activities of kallikrein-5 and kallikrein-7 in the skin of psoriatic groups. Also, mice with psoriasis had significant increases in specific pro-inflammatory cytokines (IL-1β, IL-6 and IL-12) and decreases in the anti-inflammatory cytokine (IL-10) after PSD, which were normalized after 48 h of sleep rebound. Linear regression showed that IL-2, IL-6 and IL-12 levels predicted 66% of corticosterone levels, which were selectively increased in psoriasis mice subject to PSD. Kallikrein-5 was also correlated with pro-inflammatory cytokines, explaining 58% of IL-6 and IL-12 variability. These data suggest that sleep deprivation plays an important role in the exacerbation of psoriasis through modulation of the immune system in the epidermal barrier. Thus, sleep loss should be considered a risk factor for the development of psoriasis. Public Library of Science 2012-11-30 /pmc/articles/PMC3511390/ /pubmed/23226485 http://dx.doi.org/10.1371/journal.pone.0051183 Text en © 2012 Hirotsu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Hirotsu, Camila Rydlewski, Mariana Araújo, Mariana Silva Tufik, Sergio Andersen, Monica Levy
spellingShingle	Hirotsu, Camila Rydlewski, Mariana Araújo, Mariana Silva Tufik, Sergio Andersen, Monica Levy Sleep Loss and Cytokines Levels in an Experimental Model of Psoriasis
author_facet	Hirotsu, Camila Rydlewski, Mariana Araújo, Mariana Silva Tufik, Sergio Andersen, Monica Levy
author_sort	Hirotsu, Camila
title	Sleep Loss and Cytokines Levels in an Experimental Model of Psoriasis
title_short	Sleep Loss and Cytokines Levels in an Experimental Model of Psoriasis
title_full	Sleep Loss and Cytokines Levels in an Experimental Model of Psoriasis
title_fullStr	Sleep Loss and Cytokines Levels in an Experimental Model of Psoriasis
title_full_unstemmed	Sleep Loss and Cytokines Levels in an Experimental Model of Psoriasis
title_sort	sleep loss and cytokines levels in an experimental model of psoriasis
description	Up to 80% of people develop a cutaneous condition closely connected to their exposure to stressful life events. Psoriasis is a chronic recurrent inflammatory skin disorder with multifactorial etiology, including genetic background, environmental factors, and immune system disturbances with a strong cytokine component. Moreover, psoriasis is variably associated with sleep disturbance and sleep deprivation. This study evaluated the influence of sleep loss in the context of an animal model of psoriasis by measuring cytokine and stress-related hormone levels. Male adult Balb/C mice with or without psoriasis were subjected to 48 h of selective paradoxical sleep deprivation (PSD). Sleep deprivation potentiated the activities of kallikrein-5 and kallikrein-7 in the skin of psoriatic groups. Also, mice with psoriasis had significant increases in specific pro-inflammatory cytokines (IL-1β, IL-6 and IL-12) and decreases in the anti-inflammatory cytokine (IL-10) after PSD, which were normalized after 48 h of sleep rebound. Linear regression showed that IL-2, IL-6 and IL-12 levels predicted 66% of corticosterone levels, which were selectively increased in psoriasis mice subject to PSD. Kallikrein-5 was also correlated with pro-inflammatory cytokines, explaining 58% of IL-6 and IL-12 variability. These data suggest that sleep deprivation plays an important role in the exacerbation of psoriasis through modulation of the immune system in the epidermal barrier. Thus, sleep loss should be considered a risk factor for the development of psoriasis.
publisher	Public Library of Science
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511390/
_version_	1611936986878181376

Sleep Loss and Cytokines Levels in an Experimental Model of Psoriasis

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